POMC and Werner syndrome: Examining the long-term relapse rates is important for assessing whether the treatment response is maintained.3Relapse occurs in 50% of patients during the 1st year of follow-up after initial CER.16, 22In the continuation of the International Collaborative Infantile Spasms Study, 7% of relapses occurred following CT (vigabatrin and prednisolone or ACTH) in patients newly diagnosed with WS.13In contrast, we observed 3 times more relapses than those observed in that study at the 1-year follow-up visit.