Next, to explore the effect of treatment with SSRIs, we employed the same analysis strategy and identified 59 DMRs associated with treated GAD/MDD, of which regions associated with genes involved in cell cycle control (ANKLE2 and STMN3), glycoprotein homeostasis (ASGR1 and CDH4), and non-coding regulatory genes (BDNF-AS and ZFAT-AS1) were identified as the key processes altered by this disease. This evidence concerns the gene ANKLE2 and generalized anxiety disorder.