To refine our analysis, we focused on DMRs and identified 73 associated with untreated GAD/MDD, of which several regions associated with genes involved in apoptosis and cell cycle control (DAPL1 and VDAC2), cellular growth (RPTOR), and biosynthesis (AGPAT3, CAND2, and PGS1), were identified as key processes altered by the disease. Here, RPTOR is linked to major depressive disorder.