SNCA and Parkinson disease: Pathogenic variants in several genes are considered the main causes (and/or high-risk factors) for PD; these include LRRK2, SNCA (MIM: 163890), RAB32 (MIM: 612906), and VPS35 (MIM: 601501), where one pathogenic variant is enough to substantially increase the risk for disease (autosomal dominant), and PRKN, PINK1 (MIM: 608309), and PARK7 (MIM: 606324), which only cause disease when both copies of the gene harbor pathogenic variants (autosomal recessive).