GBA1 and Parkinson disease: Concerning progression, there is an overlap between risk and progression alleles, particularly common and rare variants at GBA1. Still, there are also non-PD risk variants that have been identified from progression analysis that represent targets for gene therapy, including APOE (MIM: 107741), LRP1 (MIM: 107770), RIMS2 (MIM: 606630), TBXAS (MIM: 274180), and SYT11 (MIM: 608741).