Phenotypic observations in humans and mice suggest that disorders such as sclerosing osteogenesis imperfecta (excessively thick bones) and phospholipidosis (excessive accumulation of phospholipids) can be ameliorated by inhibition of TRIC-B (Hu and Gulyaeva, 2019). The gene discussed is TMEM38B; the disease is osteogenesis imperfecta.