This is a disease model characterized by the deposition of CaOx crystals in the kidneys, progressive tubule damage, and inflammation like those seen in humans with oxalate nephropathy.[44, 45] In the nephrocalcinosis model, Tnfrsf11a‐Zc3h12ccKO mice lost body weight more rapidly and had a lower GFR and higher serum creatinine levels on day 8 (Figure 2O–Q). The gene discussed is TNFRSF11A; the disease is nephrocalcinosis.