MCU and type 1 diabetes mellitus: For example, in a mouse model of type 1 diabetes, reduced MCU expression and mitochondrial Ca2+ uptake were ameliorated by AAV‐mediated MCU upregulation, which restored mitochondrial Ca2+ uptake, pyruvate dehydrogenase activity, mitochondrial respiration, and both systolic and diastolic cardiac function (Suarez et al., 2018).