RRM2 and neoplasm: This suggeststhat RRM2 plays a critical role in DNA replication and repair, therebyproviding strong growth and repair capabilities to both tumor cellsand vascular endothelial cells within the tumor microenvironment.Prior studies have highlighted the important role of RRM2 in tumorgrowth and chemotherapy resistance. Inthis study, we confirmed that high RRM2 expression is not only closelyassociated with tumor cell proliferation and survival but also playsa key role in damage repair.