RRM2 staining of thetumor tissue (Figure E) revealed that cisplatin treatment alone barely reduced RRM2 expressionwithin the tumor, whereas palmatine partially reduced RRM2 expression.However, due to the lack of targeting, its efficiency was still limited.P-Fe3O4@Pal@HM combined with NIR fully amplifiedpalmatine’s effects, effectively inhibiting RRM2 expressionin tumor tissue. The gene discussed is RRM2; the disease is neoplasm.