SOD1 and rheumatoid arthritis: Previous studies have demonstrated that corynoline has the potential to reduce ROS production and lipid peroxidation in the colon tissues of DSS-treated mice and alleviate oxidative stress injury in rats with rheumatoid arthritis induced by Freund’s adjuvant arthritis (CFA) by increasing glutathione (GSH), catalase (CAT), and SOD activities while reducing MDA levels15,23.