SLC35B4 and hepatocellular carcinoma: For instance, SLC35G5 is reportedly upregulated in cisplatin-resistant lung cancer cells compared to that in cisplatin-sensitive cells.(49) Moreover, upregulation of SLC35G3 in colorectal cancer tissues has been associated with poor patient prognosis, while SLC35B4 gene upregulation has been observed in multi-resistant hepatocellular carcinoma cells compared to that in non-resistant cells.(50) These findings further support the notion that positive regulation of the SLC35 family genes may indicate greater chemoresistance.