ADRB2 and asthma: Missense variants of the ADRB2 gene, such as rs1042713 (G46A) and rs1042714 (G79C), which promote amino acid changes and affect receptor structure and function,23,24 were associated with SNP rs1042717 and genotype sets linked to asthma control and a lack of acute response to short-acting bronchodilators in severe asthma patients evaluated longitudinally.