Importantly, we observed the asymmetric localization of variant histone H3.3 at PML-NBs (Fig 4A, white arrows), which likely reflects the transition of histone H3.3/H4 heterodimers deposited at PML-NBs by Daxx into cellular chromatin undergoing active remodelling prior to infection [49–51,76,77]. Here, DAXX is linked to infection.