This research combinedly investigated four transcriptomics datasets both KC (GSE15641, GSE38424) and T2D (GSE29226, GSE25724) and suggested six shared significant genomic biomarkers (JUN, CD74, TFRC, CREB1, MCL1, SCARB1) by Limma approach, pathways, as well as regulators for prognosis, diagnosis and therapies of KC patients with T2D. The gene discussed is CREB1; the disease is keratoconus.