SMAD5 and type 2 diabetes mellitus: For exploring the candidate drugs for T2D and KC we considered 6 sKGs (CD74, TFRC, CREB1, MCL1, SCARB1 and JUN) and 3 regulatory TFs proteins (SMAD5, ATF1, NR2F1) and 156 drug receptors which has collected from Database and published article (Table S1 in S1 File).