This canalso be observed in the case of soluble sperm proteins such as PLCZ1, where loss ofactivity mutations in humans corresponded to a lack of Ca2+oscillation-inducing ability and male infertility, while Plcz1-KOdid not result in infertility outright, instead resulting in subfertility with aseverely reduced litter size in all cases. The gene discussed is PLCZ1; the disease is Infertility.