Future studies will investigate whether the TGF-β1/TNF-α axis also regulates neutrophil recruitment in poorly aggressive breast tumors using HR+ breast cancer cell lines that show minimum neutrophil recruitment abilities (SenGupta et al., 2021b) and whether tumor-derived CXCL1/8 modulates neutrophil function to promote cancer cell aggressiveness. The gene discussed is CXCL1; the disease is cancer.