The approach used in our study, which aimed to identify general transcriptomic signatures of the tumor components rather than individual gene alterations to obtain an initial comparative overview, conceptually differs from that of another recent ST-based study on a single case of combined large-cell neuroendocrine carcinoma of the lung, where the analysis focused primarily on a single gene, SMC1A [14]. Here, SMC1A is linked to large cell neuroendocrine carcinoma.