MYC and adenocarcinoma: Notably, the copy number gains of both MYC and LZTR1 were particularly pronounced in the SC-NEC (MYC: 25.0, LZTR1: 56.16) and sarcomatoid areas (MYC: 29.02, LZTR1: 58.18) compared to the adenocarcinoma (MYC: 14.3, LZTR1: 22.88) and adenoma (MYC: 10.13, LZTR1: none) compartment (Fig. 9B).