MED12 and non-small cell lung carcinoma: To investigate the mechanism of RTK inhibitor (RTKi) resistance induced by the functional loss of MED12, we analyzed RNA sequencing (RNA-seq) data from non-small cell lung cancer (NSCLC) patients with MED12 mutations available in The Cancer Genome Atlas (TCGA) database, as well as from MED12 knockout (KO) H3122 and PC9 cell lines, utilizing Gene Set Enrichment Analysis (GSEA).