EZH2 and chronic kidney disease: Enhancer of zeste homolog 2 (EZH2), a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3), has been reported to be increased in the fibrotic kidneys of mice with UUO and in patients with CKD, suggesting that this methyltransferase has profibrotic functions.