A subset of these genes, including 2700049A03 Rik, chemokine (C–C motif) receptor 9 (Ccr9), familial glucocorticoid deficiency type 2 (Fgd2), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3), and syndecan 4 (Sdc4), exhibited altered promoter methylation and corresponding changes in gene expression in an independent cohort of renal tissues [81]. The gene discussed is SDC4; the disease is familial glucocorticoid deficiency.