CCL2 and acute kidney injury: Conversely, studies have demonstrated that increased global H3K9/18 acetylation, particularly in inflammatory genes such as Ccl2, Icam-1, and Vcam-1, and locus-specific H3/4 acetylation in genes such as Il6, Il12b, and Serpine1, is associated with upregulated gene expression in mouse models of ischemia–reperfusion (IR) and lipopolysaccharide (LPS)-induced AKI.