TBK1 and neoplasm: Unlike microglia, TBK1-regulated TAM function in BCBM is independent of tumor subtypes, as our preclinical trials demonstrated that TBK1 inhibition impairs BCBM across TNBC (e.g., MDA-MB-231-Br, 4T1), ER+ (e.g., E0771), and HER2+ (e.g., BT-474-Br) models.