ALDH2 and hepatocellular carcinoma: Similarly, Abe et al.108argued that ALDH2 polymorphism is closely related to ethanol consumption patterns, and both ALDH2 polymorphism and duration of alcohol use influence the development of HCC in patients with alcoholic liver cirrhosis, and Ye et al.116reported that ALDH2 polymorphism is linked to significant variations in HCC susceptibility.