In the context of CSS, pivotal clinical and pathological variables, such as albumin (p = 0.023), alkaline phosphatase (p = 0.023), gamma‐glutamyl transferase (GGT, p = 0.035), prothrombin time (p = 0.047), haemoglobin (p = 0.008), CRP (p = 0.001), intraoperative PRBCs (p = 0.009), intraoperative FFP (p = 0.005), MVI (p = 0.001), LVI (p = 0.001), UICC tumour stage (p < 0.001), pathological T category (p = 0.015), N category (p < 0.001), duration of hospitalisation (p = 0.023), and perioperative complications (p = 0.011) displayed significant associations in the univariate analysis (Table S3). The gene discussed is F2; the disease is neoplasm.