Although Hou et al. previously suggested that DAZAP2, along with VTA1 and KFL5, regulates host cell responses to SARS-CoV-2 infection by controlling the SERPINE1 expression (associated with COVID-19 severity), we found that editing SERPINE1 had no effect on infection by authentic SARS-CoV-2 or trVLP-NLuc particles (Fig. 4G and H). Here, SERPINE1 is linked to COVID-19.