Interestingly, RBP3 upregulation has been shown to prevent photoreceptor degeneration in diabetic rodents through VEGF inhibition (Yokomizo et al., 2019), suggesting that RBP3 could also be beneficial in diseases characterized by photoreceptor loss and VEGF dysregulation, such as AMD. Here, RBP3 is linked to age-related macular degeneration.