This analysis confirmed that HTRA1 WT overexpression caused age-related retinal degeneration across the entire retina (Fig. S1F, 6 months; Fig. 2E, 11 months), and further showed that the loss is largely due to photoreceptor degeneration (Fig. 2E; photoreceptor loss in the ONL, compared to loss in the rest of the retina). Here, HTRA1 is linked to retinal degeneration.