GCDH and glutaryl-CoA dehydrogenase deficiency: Genomic sequencing analysis revealed the relation between mutations in the gcdH gene and the occurrence of glutaric aciduria type I (GAI).[44] MYCi975 is a small molecule inhibitor suppressing the expression of GcdH.[39, 45] As expected, addition of MYCi975 may decrease the glutarate catabolism through GcdH and resulted in elevated levels of glutarate within HEK293FT cells (Figure 6I).