Mechanistically, we demonstrated that SP1 transcriptionally activated the key glycolytic enzyme 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFKFB4), thereby regulating aerobic glycolysis, which maintains tumor growth and survival.[12] These findings demonstrated that metabolic remodeling occurs early, before the onset of advanced PDAC, and plays a critical role in tumorigenesis and tumor progression. The gene discussed is SP1; the disease is neoplasm.