FGL1 and obesity due to melanocortin 4 receptor deficiency: In order to investigate the contribution of hepatocyte‐derived FGL1 in MASLD, 6–8 week‐old Fgl1LWT and Fgl1LKO male mice were fed a normal chow or a western diet for 16 weeks to induce obesity coupled with reduced glucose tolerance, hepatic steatosis, and inflammation [33].