These cellular defense processes have crowned microglia as perhaps the most important cell type in the control of amyloid burden in AD.[41] Besides, platelet activation increases plasma Aβ levels, contributing to AD pathogenesis.[44] Additionally, Aβ and astrocytes‐derived APOE form an APOE‐Aβ complex which is cleared by a very‐low‐density lipoprotein receptor at the blood‐brain barrier.[45]. Here, APOE is linked to Alzheimer disease.