Besides, APOE remains the most significant genetic risk factor for AD, implicated in processes such as Aβ peptide aggregation and clearance, tau neurofibrillary degeneration, microglial and astrocytic responses, and blood‐brain barrier disruption—all of which contribute to cognitive decline.[45] In contrast, the transcriptional levels of GEMIN7 are minimal across cortical cell types (Figure 5b,d). Here, APOE is linked to Mental deterioration.