These findings are consistent with those of a previous study, in which the authors proposed Nrf2 to be an intermediary molecule in the regulation of microglial function to induce an Arg‐1+ microglial phenotype that attenuates the neuroinflammatory response in depression.[53, 54] We accordingly speculate that ACT and FA have antidepressant and anti‐inflammatory effects associated with the regulation of the microglial phenotype, which is mediated via the Nrf2 signaling pathway. This evidence concerns the gene ARG1 and major depressive disorder.