BANF1 and Coffin-Siris syndrome: CSS is inherited in an autosomal dominant pattern, but it is most often caused by de novo mutations in components of the BAF, also known as the SWI/SNF, chromatin remodeling complex, including ARID1A, ARID1B, ARID2, DPF2, SMARCA2, SMARCA4, SMARCB1, SMARCC2, SMARCE1, as well as in PHF6, which functions cooperatively with BAF (Vergano and Deardorff 2014; Mittal et al. 2024).