APOE and familial hypercholesterolemia: ARWMC rating scales for five regions were evaluated to assess the potential relationship between the regional distribution of WMH and the presence of CMHs, using Spearman's partial rank correlations (adjusting for age, sex, BMI, region of residence, education, APOE ɛ4 genotype, amyloid status, hypertension, type 2 diabetes, and hypercholesterolemia; Figure 2).