CD8A and colorectal carcinoma: Our recent study demonstrated that immunizations of immunocompetent wild-type B6 mice with nonreplicable (MMC-treated or irradiated) MC38 CRC cells plus rGRA6Nt adjuvant activate CD8+ cytotoxic T cells against the CRC cells and inhibit the growth of the tumors of the identical cancer cells after its challenge implantation of 1 × 106 cells16.