CD8A and cancer: We recently discovered that the amino-terminus region (amino acids 41–152) of dense granule protein 6 (GRA6Nt) of Toxoplasma gondii, an intracellular protozoan parasite, functions as a powerful adjuvant when used in immunization with nonreplicable MC38 CRC cells to activate cancer-specific CD8+ cytotoxic T cells, and that the immunization using GRA6Nt adjuvant markedly inhibits the growth of tumors of the identical CRC after its challenge implantation16.