JAK2 and liver dysplastic nodule: Further supporting this paradigm, Deng et al. integrated UPLC-MS/MS, network pharmacology, and transcriptomics to elucidate the multi-component synergy of Schisandra chinensis fruit mixture in DN, identifying schisandrin and quercetin as core bioactive compounds that ameliorate renal fibrosis through JAK2/STAT3 and TGF-β/Smad pathway inhibition (Deng et al., 2025).