In DN mice, combined therapy significantly reduced 24-h urinary protein (358.54 ± 21.21 mg/L vs. 1046.48 ± 72.84 mg/L in the model group, p < 0.001), improved serum creatinine/urea nitrogen, and downregulated IL-6/TNF-α expression. This evidence concerns the gene TNF and liver dysplastic nodule.