SAV1 and endothelial dysfunction: Liu S. et al. (2021) utilized gene therapy to knock down the Hippo pathway gene Salvador (Sav) in an ischemia/reperfusion pig model to promote myocardial cell renewal and enhance cardiac function. Wang et al. (2016) discovered that endothelial YAP/TAZ activity was influenced by varying blood flow patterns and was linked to endothelial dysfunction and the development of atherosclerosis.