Lysine-specific demethylase 6B (KDM6B), is a key histone demethylase in various normal and pathological processes such as inflammation, development, aging, and cancer (Salminen et al., 2014).High levels of KDM6B have been confirmed to regulate tumor progression by mediating cell proliferation, migration, and senescence (Cheng et al., 2025; Xun et al., 2021). The gene discussed is KDM6B; the disease is cancer.