Schisandrin B has been shown to induce autophagy in Human hepatoma cell line (HepG2) cells, potentially via modulation of the Epidermal growth factor receptor (EGFR)/Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian target of rapamycin (mTOR) signaling pathway in acetaminophen-induced liver injury models (Li et al., 2023c). Here, AKT1 is linked to hepatocellular carcinoma.