Moreover, Schisandrol B reduces atypical cell death induced by Apoptotic protease-activating factor 1 (Apaf-1) inflammasomes through the PXR/Forkhead box protein O1 (FoxO1)/Apaf-1 axis, thereby mitigating cholestasis-induced liver damage (Liang et al., 2022). Here, APAF1 is linked to cholestasis.