However, the study by Li X et al. in ALL children contradicts our findings, showing higher ALB as a risk factor for MTX-induced leucopenia (OR = 1.084, 95% CI: 1.003–1.171, p = 0.041) and neutropenia (OR = 1.101, 95% CI: 1.019–1.189, p = 0.0015), the odds ratios were very close to 1, suggesting a relatively weak association that may lack clinical significance (Li et al., 2019). This evidence concerns the gene ALB and Decreased total neutrophil count.