This correlation was also observed by Khera S et al., where lower ALB levels (<35 g/L) were an independent risk factor for MTX-induced nephrotoxicity in pediatric ALL patients (OR = 4.71, 95% CI: 1.06–9.86, p = 0.04) (Khera et al., 2022). The gene discussed is ALB; the disease is acute lymphoblastic leukemia.