The experiment employed a multidose gradient design combined with molecular biology detection (MAO-B/ROS/SOD), behavioral assessments (water maze, open field experiment), and immunofluorescence technology, revealing for the first time that the combined inhibition of D1/D2 receptors causes the loss of dopaminergic neurons and induces spatial memory impairment and anxiety-like behavior in a dose-dependent manner by exacerbating oxidative stress damage. Here, MAOB is linked to Anxiety.