Furthermore, α-lipoic acid protects dopaminergic neurons effectively by suppressing NLRP3 inflammasome activation and its mediated GSDMD pathway, concurrently downregulating S100A9 protein expression, thereby emerging as a novel therapeutic strategy for PD (Saad, Atef & Elsayed, 2025; Zhang et al., 2025). This evidence concerns the gene NLRP3 and Parkinson disease.