Moreover, western blot analysis demonstrated that the cancers after being cultured on tissue-mimicking IPN hydrogels exhibited elevated expression of E-cadherin, decreased expression of vimentin and Snail/Slug; the results together supported the inhibition of EMT and induction of MET biomolecular features in cancer cells on tissue-mimicking IPN hydrogels (Fig. S10c). Here, SNAI1 is linked to cancer.