CXCL8 and metabolic dysfunction-associated steatohepatitis: In humans, increased serum IL-8 levels have been demonstrated in chronic liver diseases such as alcohol-associated hepatitis and metabolic dysfunction-associated steatohepatitis (MASH) [51,52], and recent reports suggested a possible association between 6PPD/6PPD-Q exposure and the development of MASH [32,33,53].