As shown in the figure, male patients with EOAD were associated with gait dysfunction [Odds Ratio (OR) = 10.797, 95%, CI, 3.257–35.792, p < 0.001], peripheral vascular disease (OR = 3.835, 95% CI, 1.767–8.321, p < 0.001), Chronic Obstructive Pulmonary Disease (COPD) (OR = 5.984, 95% CI, 2.186–16.381, p < 0.001), the use of cholinesterase inhibitors (ChEIs) (OR = 3.141, 95% CI, 1.881–5.244, p < 0.001), memantine (OR = 1.587, 95% CI, 1.029–2.447, p = 0.037), and alcohol use (OR = 1.801, 95% CI, 1.155–2.809, p = 0.010). This evidence concerns the gene BCHE and chronic obstructive pulmonary disease.