The PGV rate was largely contributed to by BRCA2 (1.7%), ATM (1.3%), CHEK2 (1.1%) and BRCA1 (0.5%) and PGVs in these genes were found at significantly higher rates in the high risk localized and advanced PCa cohort compared to cancer-free males. The gene discussed is CHEK2; the disease is posterior cortical atrophy.