EZH2 and adenocarcinoma: We specifically noted spatial distribution with NEPC MR-TFs enriched within L2 and L2.1 subpopulations (module 0), transition MR-TFs enriched in L2.1, basal, and L1.1 subpopulations (module 1), and adenocarcinoma MR-TFs enriched in basal, L1.1, and L1.2 (module 2), again emphasizing the important control by EZH2 on these cell state transitions (Fig. 1F–G).