To investigate how EZH2 shapes the epigenetic landscape and contributes to phenotypic plasticity in PCa, based on the ChIP-seq profiles of H3K4me3 and H3K27me3 we classified the chromatin into four major states: (i) Active (H3K4me3+ only), (ii) Repressed (H3K27me3+ only), (iii) Bivalent (both H3K4me3+ and H3K27me3+), and (iv) Unmarked (neither mark). This evidence concerns the gene EZH2 and posterior cortical atrophy.