Upstream, multiple inflammasome sensors may be involved: NLRP3 is the most studied and responds to mitochondrial ROS, Ca2+ flux, and ion imbalances during reperfusion (19, 20), but AIM2 (activated by DNA from necrotic cells) may also drive caspase-1 in MI, as suggested by elevated DNA-sensing pathway activation in infarct tissue (19, 21). The gene discussed is CASP1; the disease is myocardial infarction.