By inhibiting the expression of Bax, cleaved caspase-3, caspase-3, and Cyt-c, and increasing the expression of antiapoptotic proteins such as Bcl-2, Bushen Huoxue Formula might alleviate IDD and inhibit the development of inflammatory factors (Gao et al., 2024). The gene discussed is CASP3; the disease is intervertebral disk degenerative disorder.