Chinese herbal medicines, including Bushen Huoxue Decoction (Shuaihua et al., 2015; Shuaihua et al., 2018; Ren et al., 2017), Liuwei Dihuang Pills (Guohua et al., 2015), Shentong Zhuyu Decoction (Demin et al., 2019), Shujin Qubi Decoction (Yuxiang et al., 2018), Tongluo Decoction (subred et al., 2015), Zhiqiao Gancao Decoction (Jiangtao et al., 2016), and Fufangqishe-Pill (Liang et al., 2010), have been shown to alleviate IDD by reducing the expression of IL-1β and (or) TNF-α in vitro experiments and animal models. Here, IL1B is linked to intervertebral disk degenerative disorder.