PTGS2 and Sepsis: LPS-induced sepsis models show elevated ferroptosis markers (e.g., prostaglandin-endoperoxide synthase 2 (PTGS2), malondialdehyde (MDA), and lipid ROS), which are associated with increased disease severity, while ferroptosis inhibitors, such as dexrazoxane and ferrostatin-1, alleviate LPS-induced mitochondrial damage (48).