GSDME and Yersinia infectious disease: Additionally, caspase-3 and caspase-8-dependent pathways can induce pyroptosis: chemotherapeutic agents trigger pyroptosis via caspase-3-mediated cleavage of GSDME (28), while Yersinia infection induces pyroptosis through caspase-8-mediated cleavage of GSDMD (29, 30).