Subsequent serological assessment demonstrated markedly elevated levels of antinuclear antibodies (ANA), anti-dsDNA, SSA/Ro 60, and SSB/La antibodies, thereby fulfilling the 2019 EULAR/ACR (European League Against Rheumatism/American College of Rheumatology) criteria for the diagnosis of SLE [7]. Here, TRIM21 is linked to systemic lupus erythematosus.