The functional disruption of intracellular transport and synaptic networks that result in a build-up of accumulation of misfolded proteins like amyloid beta (Aβ), tau, α-synuclein (α-syn) and TAR DNA-binding protein 43 (TDP-43) are found in AD, PD and ALS, respectively. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.