TLR3 and infection: However, the comparison of genotypic and allelic frequencies for TLR3 rs3775291 C/T among individuals with HTLV-1 according to the presence and absence of symptoms associated with infection showed that asymptomatic individuals had a higher frequency of the polymorphic genotype (p= 0.0206; OR= 0.24) and allele (p= 0.0044; OR= 0.48) (TT and T, respectively; Table 2).