Figure 2C shows the first 10 differential metabolites. Levels of nine metabolites, such as O-Phosphothreonine, Morpholine, and Diethanolamine, were decreased in postmenopausal women. Conversely, chenodeoxycholic acid glycine conjugate levels were moderately increased in postmenopausal women. The KEGG analysis showed that significantly differential pathways included Central carbon metabolism in cancer, Nucleotide metabolism, ABC transporters, Alcoholism, etc (Figure 2D). The gene discussed is ABCG2; the disease is alcohol dependence.