In their investigation utilizing a K14-HPV16 transgenic mouse model, characterized by HPV-driven spontaneous cervical cancer development, they discovered that effectively eliminating the E7 gene led to the restored expression of CDK2, E2F1, and RB, thereby triggering apoptotic pathways in tumor cells and effectively reversing the progression of cervical cancer (Gao et al., 2022). This evidence concerns the gene RB1 and neoplasm.