E2F1 and cervical cancer: In their investigation utilizing a K14-HPV16 transgenic mouse model, characterized by HPV-driven spontaneous cervical cancer development, they discovered that effectively eliminating the E7 gene led to the restored expression of CDK2, E2F1, and RB, thereby triggering apoptotic pathways in tumor cells and effectively reversing the progression of cervical cancer (Gao et al., 2022).